The following browser tip of tregoweth's should probably be listed here, since it's the one that's saved me the most labour since joining E2:

Today's handy tip: maintaining multiple E2 accounts on one computer

Pedantic users who always search from the front page to avoid random softlinking may find this a timesaver:

how to avoid creating irrelevant softlinks

For those new to E2 who haven't visited User settings yet, go there. If something about the Everything page design is narking you, chances are it's configurable here. In particular, people who find their current E2 font almost unreadably small should try out the different themes.