In addition to methaqualone, Mandrax contains an antihistamine (diphenhydramine), which has a synergistic effect. This combination can either increase the sedative effect, or simply enhance the hypnotic and euphoric effect. Users should be careful with their consumption of alcohol along with Mandrax, until they know their tolerance. Also called "mandies". In some circles, Mandrax is smoked in a pipe with marijuana, rather than ingested.