The Pope is one of the most laid back people on the planet. This isn't the sort of Jeff Lebowski (bka the Dude) laid back, this is serious, ain't-foolin'-around laid back. I mean, if you were the Bishop of Rome and leader of the Roman Catholic Church, you'd have to be pretty chill all the time. It's part of his job description to be as Christlike as he can. Jesus was one seriously laid back dude.
So if something was going to piss off the Pope, it would have to be some serious, DEFCON 2 type shit. Something worse than Keyser Soze, Charles Manson and your pubescent older brother could ever whip up.
I first heard this from my good friend J.T., in reference to a Java program he had just written.