U.S. Interstate highway extending from Portsmouth, Virginia to just west of St. Louis, Missouri. Principal cities along the route include Norfolk, VA, Richmond, VA, Charleston, WV, Lexington, KY, Louisville, KY, Evansville, IN (actually just off of 64 on Interstate 164), and St. Louis, MO.

Intersects with Interstates 95, 81, 77, 75, 71, 65, 57, 55, and 70.

I have travelled the full length of this road, minus approximately 6 miles west of St. Louis between downtown and the Interstate 270 beltway. Observations from east to west: beach, sprawl, mountains, mountains, hills, sprawl, corn, corn, corn, corn, and sprawl. Not very exciting, in other words.