U.S. Interstate highway running from just east of Knoxville, Tennessee to the Canadian border in New York state. Runs basically along the Appalachian Mountains, and though it doesn't really pass through any major cities, it is very heavily travelled, especially by truckers.

Highlights along the road are the Tri-Cities, TN/VA area, Virginia Tech in Blacksburg, VA about 10 miles down U.S. 460 from Exit 118B in Christiansburg, VA, Roanoke, VA, Harrisburg, PA, Scranton, PA, and Syracuse, NY.

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