Milhouse's name is taken from the Republican President, Richard Milhouse Nixon, who resigned befored he could be impeached following the Watergate scandal.

It should be noted that Milhouse's parents bear an uncanny resemblance to each other, despite the fact that the mother hails from Shelbyville, as disclosed in the 'Lemon Tree' episode.

Milhouse played Fallout Boy to Rainier Wolfcastle's Radioactive man, in the ill fated movie tie in.