For more than a couple of millenia, meant the inhabitant of the Greek island of Lesbos, male or female. For the last decades or so, primarily means women of homosexual orientation.

This has recently led inhabitants of Lesbos, Lesbians (with original meaning) to file a lawsuit against the Gay and Lesbian Community of Greece, saying that the use of the word by non-Lesbians has been causing them problems in their daily social life and that the term belongs to them, the generations upon generations of the Lesbos inhabitants and not to people of a particular sexual orientation who have nothing to do with the island.

The court rejected the demand of the inhabitants of Lesbos in July 2008.