In Pink Floyd's The Wall, the worms represented knowledge, reality, life, and death (and there are more interpretations). In The Trial, Pink is forced by the worms to confront the world as it really is, without his wall. There are multiple references to the worms throughout the two disc album - they are usually regarded as a fearsome thing.

Knowledge is power - it can be used for good or evil. Nothing can defy nature. If, like Pink, we choose to ignore reality, we won't be able to deal with it when it finally breaks through our wall.