A palindromic sequence is a DNA or RNA sequence that reads the same on the complementary strand. It is not a sequence that reads the same forwards and backwards.


  • AATCGCGATT is a palindromic sequence,
  • AATCGGCTAA is not
Palindromic sequences are interesting because they are hotspots for mutation. Palindromic DNA sequences in Bacteria appear to be more prone to mutation than non-palindromic sequences.

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