A type of mutation in which one or more paired nucleotides are inserted or deleted in the coding region of a gene, which causes the triplet codons to be read in the wrong frame; the resulting polypeptide has a garbled amino acid sequence from the mutated codon on.

From the BioTech Dictionary at http://biotech.icmb.utexas.edu/. For further information see the BioTech homenode.

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