Angiotensin is part of the renin-angiotensin-aldosterone
system. It does not generally exist simply as angiotensin
, but rather as angiotensinogen
, before it is cleaved into angiotensin I
and then converted to angiotensin II
by angiotensin converting enzyme
which is located mostly in the lungs
Angiotensinogen and angiotensin converting enzyme are normally present in large amounts in the system, but cannot be activated and used, respectively, until renin is present. It is a large molecule, produced in the liver, and only a small part of it is cleaved off to become angiotensin I.
Angiotensin II is present in large amounts when body salt content is low, and in small amounts when there is enough sodium in the system.
These are my interpretation of my lecture notes, but I may have used some references from Hole's Anatomy and Physiology (Shier, Butler, Lewis) and Human Physiology (Vander, Sherman, Luciano)