I do not endorse mixing medication and alcohol, but have on several occasions successfully taken codeine during booze-ups. It made me serene and happy and I stopped worrying about my ex-girlfriend, which can only be considered a Good Thing.

However, one of the side effects of codeine use is constipation (I'm told this is true for morphine as well), something which is only made worse by an excrutiating hangover. So the day after was spent largely in the john while pondering the not so glamourous side of recreational drugs...