Humans are not
unnatural.
We are as firmly embedded in our environments as any other species and the forces present in those environments will shape the future of our species.
That we craft the environments for ourselves is irrelevant to evolution. We may change the variables that ensure our reproductive success (or failure, as the case may be) but these new pressures will work in the equations just as well as the old ones.
What sort of human might we expect to thrive in our new natural environment? A resistance to repetitive stress injury will play a role. So too will the ability to acclimate to the new techologies and social changes that are occurring at an apparently ever increasing pace. The tendency of people to marry (and remarry) later in life will benefit those that age well in our youth obsessed culture.
Not all humans will thrive equally in the sedentary, high-fat, toxin laced cesspool we're racing towards. That inequality is all that it needed for evolution to continue.