Protriptyline, unlike most tricyclic antidepressants, can have a stimulatory effect. It is thus often used with depressive patients with hypersomnia.

Some drug interactions with protriptyline you should know about:

There are other drug interactions patients on protriptyline can be affected by. Ask your doctor or pharmacist. You shouldn't rely solely on the Interweb for medical information.

Source: Keltner and Folks, Psychotropic Drugs, 2nd ed. St. Louis: Mosby, 1997.