A fairly good American cartoon that aired in the early or mid-nineties and was of interest because it featured characterization, an ongoing plot, and resolution. It took place in a classical kind of space opera setting, and its storyline consisted of the battle between humans and Neo Sapiens.

To combat the more physically powerful Neo Sapiens, the human main characters fought in these suits called E-Frames that were somewhat similar to the 'mechs in Mechwarrior, only smaller and much less powerful.

I'm unsure of whether its end was planned or if the show was simply cancelled, however it did not end like so many tv shows by simply one day trailing off. Instead, its ending was no stupid, haphazard affair, but rather actually offered some closure. After it ended, it was exiled to tv show hell, in which networks like USA aired it at ungodly hours, and then it faded into the darkness.