This personality disorder is characterized by restricted emotional reactions and social indifference. This withdrawal and detachment from others is not motivated from fear, or discomfort, but by true disinterest in other people. This Personality Disorder is 3.5 times more common in men than in women.

Schizoid personality disorder can be confused with autism spectrum disorders, such as Asperger's syndrome, which also often include a lack of interest in social interaction.