Wolf Hirschorn Syndrome

AKA: Wolf Syndrome
AKA: 4p- Syndrome
AKA: Deletion of the Short Arm of the Fourth Chromosome.

WHS is caused by the deletion of the short arm of the fourth chromosome. The amount of material deleted may range from about 50% of the short arm to a small break that can't be detected by normal chromosome analysis. Because of the wide range of deleted material (1% to 50%), the effect on each child varies widely.

Possible Symptoms (Varies with the %deleted):
severe growth problems
mental retardation
"Greek Helmet" faces
cleft lip or palate
coloboma of the eye
cardiac septal defects
various other physical disabilities

More Information: www3.ncbi.nlm.nih.gov/htbin-post/Omim/dispmim?194190