A tongue-in-cheek slasher flick from the mid-1990s, Scream was probably known best for the killer's 'Mr. Ghostface' mask, and for the scene in which one of the characters explains "the rules":

There are certain rules that one must abide by in order to successfully survive a horror movie. For instance,
Number One: You can never have sex. Big no-no, big no-no. Sex equals death, okay?
Number Two: You can never drink or do drugs. The sin factor! It's the sin, it's an extension of number one.
And Number Three: Never, ever, ever, under any circumstances say "I'll be right back." Cause you won't be back.

The other well-known scene in Scream is the beginning, wherein Drew Barrymore receives the infamous "Do you like scary movies?" phone call from the killer. These scenes and several others from Scream and its sequels, as well as other 1990s horror movies such as I Know What You Did Last Summer and The Blair Witch Project, go on to be lampooned in the Wayan Brothers' parody Scary Movie; as some are aware already, "Scary Movie" was the working title for Scream.