Mitomycin is yet another antibiotic
, this one selectively prevents DNA synthesis
without inhibitinmg RNA
synthesis. Researchers think this is caused by the cross-link
ing of the double stranded DNA
and strand breakage. However, a natural defense mechanism is already in place, the so-called SOS response
(think about delay of cell division, release of temperate phage
s, induced synthesis of repair enzyme
It also appears to interfere with plasmid
DNA elements), and therefore used in research
with bacterial cells
to remove its activity.
The name strongly suggest that this antibiotic disrups or prevents the mitosis
though. Anyway, I'll add more info if I can find it.