LISA is an acronym standing for 'Local Indicator of Spatial Autocorrelation,' a family of statistical methods first introducted by the French geostatistician Luc Anselin in 1995. The most commonly used variant is the local Moran coefficient, which is defined as:

Ii=(zi/m2)*sumj(wij*zj)

where zk=xk-avg(x) and m2=sumk(z2k/n), and is computed for each locality i and its neighbouring localities j. The wij parameter allows the researcher to define the spatial extent of the analysis.

This coefficient can be calculated for each locality in a data series, and the significance of each value of the coefficient can be determined by permutation.

What does all of this mean? By way of a LISA analysis, a researcher in possession of a spatial data series can identify hot-spots as those localities where strong spatial processes are underway.