An antihistamine, primarily used to reduce mucus secretion (e.g., clear up stuffy nose) or allergic inflamation (e.g., make bug bites stop itching). It also has sedative effects and care should be taken when combining with alcohol or other depressants.

Diphenhydramine is commonly known in the U.S. as Benadryl™, which is the name used by the pharmaceutical company Warner-Lambert. It is sold over the counter in tablets or capsules.