Interstate 4 connects Tampa to Daytona Beach via Lakeland, Orlando, and Sanford. The route originally went to Saint Petersburg on current Interstate 275. FDOT considers the route to be state route 400, which continues into Daytona Beach from the east end at Interstate 95.
I-4 goes through downtown Orlando because of the efforts of Martin Andersen, an influential businessman who also got Florida's Turnpike to pass near Orlando. The original proposed alignment would have left the current alignment around Kirkman Road and gone north and northeast to return to the current alignment near either Maitland Boulevard or Lake Mary Boulevard.