The "classic" physical symptoms of Turner's syndrome include puffy hands and feet soon after birth, webbing of the neck, an unusually broad chest, and small nipples.

The severity of Turner's syndrome may vary widely from individual to individual, because (as mentioned in a previous writeup) many females may be "genetic mosaics". During the course of their early embryonic development, one or more of their differentiating cells lost an X chromosome so that when they were born, some of their cells were missing an X, but the other cells in their bodies were perfectly normal. Presumably, a woman or girl with a higher number of XX cells than X0 cells would have a much less severe version of the syndrome than a woman or girl who was born with the X0 genotype throughout all the cells in her body.

Infants with the syndrome may have difficulty suckling (due to hard palate deformities) and may show "failure to thrive." In addition to giving girls with Turner's syndrome estrogen treatments (which can help them develop breasts and other secondary sexual characteristics), they are sometimes given growth hormones to improve their height (the success of this latter treatment varies).