Actually, imipramine (trade name in the USA: Tofranil®) is used to control nocturnal enuresis, or bedwetting, in both adults and children. It is important to note that it is not being used as an antidepressant here -- for adults, a psychotherapeutic dose is ~150mg/day, while effective doses for enuresis are 25-50mg/day. The mechanism appears to be related to the increase in epinephrine seen with the tricyclics, as well as a normalization of sleeping EEG.

Imipramine may not be a good sole treatment for enuresis, because users tend to relapse upon discontinuation. Also, despite the fact that the doses are well below the antidepressant dose, long-term use of such a powerful personality-changing chemical for a physiological problem seems a little dangerous. On the other hand, it can be invaluable when enuresis must be temporarily controlled. Also, since most people with enuresis are children, and most children grow out of it in time, a temporary fix may be sufficient.

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