Classification system devised to provide standard names for the various functional groups of proteins on a cell surface. CD stands for 'cluster of differentiation'. The system is reviewed, and new CD designations added or updated, at the Human Leucocyte Differentiation Antigen workshop which is held every year.

The CD classification system is now the accepted norm for formal designation of cell surface molecules. It has superceded previous systems, such as naming cell surface molecules according to the particular function affected by an anti-leukocyte monoclonal antibody to that molecule, or simply allowing the research group that discovered the molecule to name it.

An example of the CD system is CD14.

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