(CMT) is a genetic
condition of the peripheral nervous system
that affects the sensory and muscle control
s in the lower legs and arms. It was named for the three scientists who first noted it around the start of the 20th century.
CMT is characterized by a slowly progressive degeneration of the muscles in the foot, lower leg, hand and forearm, and a mild loss of sensation in the limbs, fingers and toes. Degeneration reaches its peak usually by about age 30, but CMT is not a fatal disease and does not affect normal life expectancy.
CMT is a genetically heterogeneous disorder, in which mutations in different genes can produce the same clinical symptoms.
Those suffering from CMT have been found to benefit greatly from a regular exercise program, which can help to maintain good movement control and to prevent stiffness and contractures.