The University of Southern Indiana began as a regional campus of Indiana State University in 1965. Twenty years later, in 1985, a legislation made USI a separate state university.

Last year 9,675 students enrolled at USI. It includes 65 international students coming from 33 nations.

In 1995, Men's Basketball team became Champion in Division II (NCAA)

It is in rivalry with University of Evansville.

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