Converts glyceraldehyde-3-phosphate (G3P) into 1,3-Bisphospho-D-glycerate (BPG). This is a vital step in glycolysis (as are all the steps) but the enzyme has some other activities
. These include binding viral RNA
which sometimes inhibits and sometimes promotes viral growth.
R-C=O -Cys-SH-> R-C-S-Cys (a thiohemiacetal) -NAD-> R-C=O
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H H (thioester) Cys-S
The cys is then deacetylated by a phosphate. In ALDH
, the same mechanism occurs, but the deacetylation step uses a water molecule to hydrolyse.