Some of my favourite movies, have been written and/or directed by brothers. And by 'brother', I do not mean people from the ghetto who use the word 'homie' a lot, I mean 2 people who share the same mother or father (or both).

Some examples:

The Wachowski Brothers (Andy and Larry) - The Matrix, Bound.

The Coen Brothers (Ethan and Joel) - The Big Lebowski, Fargo, Barton Fink, Raising Arizona, The Hudsucker Proxy and more.

The Farrely Brothers (Bobby and Peter) - Kingpin, Dumb and Dumber, There's Something About Mary, Me, Myself & Irene.

The Hughes Brothers (Albert and Allen) - Menace II Society, Dead Presidents, From Hell

And, let us not forget the Hollywood heavyweights (in more ways than one :), The Weinstein Brothers (Bob and Harvey) who started Miramax films and have produced a slew of the best movies in recent times.

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Thanks BrooksMarlin, fellow film geek...