Mitomycin is yet another
antibiotic, this one selectively prevents
DNA synthesis without inhibitinmg
RNA and
protein synthesis. Researchers think this is caused by the
cross-linking of the
double stranded DNA and strand breakage. However, a natural defense mechanism is already in place, the so-called
SOS response (think about delay of cell division, release of temperate
phages, induced synthesis of repair
enzymes, etc.).
It also appears to interfere with
plasmids (extra-
chromosomal DNA elements), and therefore used in
research with
bacterial cells to remove its activity.
The name strongly suggest that this antibiotic disrups or prevents the
mitosis though. Anyway, I'll add more info if I can find it.