Often abbreviated to "JSC", NASA's Johnson Space Center is located in Houston, TX, and is the place astronauts are referring to when they say things like "Houston, we've had a problem."

In 1961, NASA's Space Task Group was looking for a new home and Houston was selected. The Space Task Group (and its new facility) was renamed the Manned Spacecraft Center (MSC) and moved to Houston in 1962. The first permanent facilities were not available until 1964.

In 1973, the MSC was renamed the Lyndon B. Johnson Space Center.

It currently houses NASA's mission control for manned missions and is the home of NASA's astronaut's corps; much of their training takes place here.

There is a vistor's center at 1601 NASA Road, Houston, TX. About once a year JSC itself has an open day for the public.