Sufferers of Restless Legs Syndrome experience a wide range of uncomfortable sensations during inactivity, usually in the legs, but sometimes in the arms and trunk, making it difficult for them to relax and to fall asleep. These sensations are variously described as, "pulling, drawing, crawling, wormy, boring, tingling, pins and needles, prickly..." (source: National Institute of Neurological Disorders and Stroke website at http://www.ninds.nih.gov/health_and_medical/disorders/restless_doc.htm), and are accompanied by an overwhelming urge to move the affected body part. There is no known cure, and symptoms often worsen over time. Pain killers occasionally offer some relief.

Restless Legs Syndrome is also known as 'Jimmy Legs', under which name it was once featured in an episode of Seinfeld — Kramer's girlfriend suffered from it, and it was later revealed that George Costanza's mother was also a sufferer, although in actual fact, as George's father explained, she had "the Jimmy Arms.... like you w'n't beleef!".