The girl character in the comic strip Calvin and Hobbes. She is described by the creator, Bill Watterson as "earnest, serious and smart - the kind of girl I was attracted to in school and eventually married". *Derkins* is Watterson's wife's family's beagle's nickname.
Calvin is always trying to annoy Susie... like by forming the club: G.R.O.S.S. = Get Rid Of Slimy girlS.