Square's
cinematic RPG. It was used as a staging platform between
Final Fantasy VII and
Final Fantasy VIII, and much of what premiered in PE was used in
Vagrant Story.
You control Aya Brea, NYPD officer, whose past crosses that of the opera singer Melissa, aka Eve. Eve's mitochondria have rebelled, giving her superior power over humans. She is capable of influencing their cells into revolt, causing spontaneous human combustion (well, not really spontaneous, i guess), melting out into a pile of goo, and radical mutations. Aya is immune to her influence, and she soon learns that she has the same powers. Very well explained, beautiful cinematics, and pretty hard. Beating the game yields the key to the Chrysler Building, 70 floors of very tough monsters...
Based on the novel of the same name.