Fröhlich's syndrome


The disease is named for Alfred Fröhlich, the Austrian neurologist who first described its typical characteristics.


More commonly referred to as Adiposogenital Dystrophy, Fröhlich's syndrome is a relatively rare childhood metabolic disorder that occurs most frequently in males. It is most often associated with tumours of the hypothalamus or the pituitary gland.


Fröhlich's syndrome is characterized by one or a combination of the following:
Human chorionic gonadotropin (HCG) is frequently used to treat the syndrome. Interestingly enough, during the diet-crazed 50s and 60s, the hope that administering HCG to non-syndromic individuals would lead to weight-loss was shattered following some unpleasant reactions to unwarranted administration of the hormone.

In some overweight children a false diagnosis of Fröhlich's syndrome may arise when delayed sexual development is also observed. A lack of associated endocrine disturbance is sufficient to eliminate this misdiagnosis and these children normally progress to normal maturation.

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