The big gun of migraine relief. Initially injectable, now available in pill and nasal spray form. Expensive and with a semi-scary list of side effects...but it can mean the difference between a shitty, photophobic day and normal productivity.

The injectable form is also used to relieve (the suicide-inspiring) cluster headache attacks. Imitrex cuts headaches short, but it will not reduce the number of attacks you get; there may be a "rebound" if the drug wears off, requiring a second dose.

Avoid mixing with:

MAO inhibitors such as Nardil and Parnate
Ergot-containing drugs such as Cafergot and Ergostat
SSRI's--your basic Prozac, Luvox, Paxil, Zoloft, etc.