When making blotter acid, blotter paper is saturated with a solution of lysergic acid diethylamide and 100% alcohol or distilled water. Blotter acid is one of the latest ways to consume acid. Saturating sugar cubes, tablets, and injecting LSD into microdots all came before this rather simple yet effective way of delivery.

A quarter inch square of blotter paper holds the perfect amount for one dosage of LSD, about 100-200µ (micrograms), and is one of the most effective ways to deliver the drug. The amount of acid it takes to feel the effects is a far smaller amount than what could be provided with the same amount of a given adulterant. That is, the effects of adulterants such as strychnine and/or psychedelic amphetamines like 2,5-Dimethoxy-4-iodoamphetamine, are not present at that low of dosage making blotter acid one of the best and safest ways to consume acid next to sugar cubes and tablets because the appropriate amounts of other drugs can be contained within those delivery systems.