Inland lake, once the world's fourth largest fresh water sea, shared between Kazakhstan and Uzbekistan. It's now drying up because all the rivers that used to run into it have been diverted for irrigation of the cotton crop. (The shoreline has moved 90 miles since 1960 in some places.) What little water does come to it has all sorts of pesticides in it.
The soil around it is getting saltier (and full of chemicals) because it blows away from the exposed lake bed, and the people in a wide area of Central Asia are suffering from all sorts of illnesses due to the pollution.