Full Throttle is one of the greatest games I've ever had the pleasure to play. It's definitely not up for best game, though. It has minor control issues, and for a sierra-type puzzle solver, the answers to some of the stuff you have to do is downright mean. The storyline is the best I've ever seen, ever and I never plan to see one that equals it, either.
This game did a few things:

It entertained all sorts of people for what had to have been 10ish hours of gameplay.

It had a roleplaying game modeled after it, for the FUDGE system, which was totally great, as well.

It completely made a tiny band famous. The Gone Jackals were this little biker band that had one cd out, and someone on the game team found or knew them, and realized their perfection for the role.

The game follows a basic storyline that Corley Motors, the only bike manufacturer left in the world's owner is killed, and your gang is framed for it. You have to set things right, and kick a little ass on the way. Mark Hamill did several of the voices, including the main bad-guy. Within its bounds are held exploding bunnies, a bike that can jump the grand canyon, a destruction derby, and some totally great music. If you know anyone that can get you this game, play it.

Don't forget the credits, either. Biker haiku, Japanese names, and Supporting Cats.