Antidepressants Selective serotonin reuptake inhibitor (SSRI)
Whats the deal with SSRIs??
The SSRI drugs are used in treatment for depression and often in conjunction with psychotherapy. They decrease the reuptake of serotonin and, to a much lesser degree, other catecholamines, prolonging the action of serotonin and helping to stabilize mood.
The result is an elevated level of serotonin in the central nervous system (CNS) and may result in elevated mood and, consequently, reduced depression.
Citalopram / Celexa
Fluoxetine / Prozac
Fluvoxamine / Luvox
Paroxetine / Paxil
Sertraline / Zoloft
Escitalopram / Lexapro
Side effects for SSRI’s include: Anxiety, chills, mania, hypomania, seizures, tremors, hypotension, palpitations, hypoglycemia, unusual bleeding r/t platelet function, hyponatremia, dyspnea
As this drug raises levels of serotonin, other drugs that raise serotonin levels are contraindicated. These include: MAO inhibitors, amphetamines, other psychostimulants, and other antidepressants.
Serotonin syndrome is a rare but serious complication; it can be life threatening. It is the result of dangerously high levels of serotonin in the CNS. Symptoms include: agitation, confusion, diaphoresis, diarrhea, fever, hyperactive reflexes, poor coordination, restlessness, shaking, shivering, talking or acting with uncontrolled excitement, tremor, or twitching.
MAO inhibitors should be stopped for 14 days before beginning SSRI therapy, and SSRI therapy should be stopped for 14 days prior to starting MAO inhibitor therapy.