Stuffit is definitely a killer app, but most of what JayBonci mentions is solely the StuffIt expander / compressor. This application acts similar to Winzip and Winrar except that it handles SO many more file types. StuffIt is able to efficiently work with the following:
    Apple Single
    Arc
    Arj (works on all platforms but Macintosh)
    Binhex
    BtoAText
    Bzip2
    CompactPro (works only on Macintosh)
    UnixCompress
    GZip
    Lha
    MacBinary
    MIME
    PrivateFile
    RAR
    Self-extracting archives (MAC or Windows)
    Stuffit Segments (like rar partials... sorta)
    Shrinkwrap & DiscCopy images (Mac only)
    StuffIt file format (.SIT)
    Stuffit X (.SITX)
    Tar
    UU
    Zip
The stuffit file type and stuffit expander works for any system (mac, win, unix) and it's compression ratio is greater than both rar and zip in most situations. Aladin (the company that produces Stuffit) claims Compression as high as 98% can be acchieved using StuffIt (ie a 96 meg file into a 2.7 meg file) and can be done QUICKLY (compression mentioned before takes only 6 minutes as opposed to winzip which would take 13). Aside from being extremely compatible, StuffIt is highly secure offering 512 bit encryption of files. Yay privacy! Lastly, as mentioned above this information simply refers to the Stuffit Expander. There are also applications like the Stuffit Joiner (combines, for example, a rar file split into 15 parts back into one file) and an image mounter (reads bin, img, and other image file types).