When Scott Adams put Tina the Tech Writer in his strip (Dilbert) many, many women wrote in complaining that she was a "negative female stereotype". So he added "Antina", a muscular female with "male" interests and personality.
People complained that he was making fun of lesbians.

In Seven Years of Highly Defective People, Adams points out that in one strip, nobody complained that Wally was acting like a stereotypical man.

Also, in the sunday strip where Wally stole Dilbert's lunch, and as punishment, Dilbert, anticipating the theft, had laced the lunch with female hormones turning Wally into a female. A lot of females wrote in complaining that he was implying that being female is a punishment.