A specific stereochemical arrangement of amino acid residues in serine proteases that is characterisic of this class of proteases and that is responsible for their catalytic activity.
The residues are:
This is what it looks like, roughly (the imidazole ring is, naturally, pentameric - but it's easier to draw this way!)
Ser-O-H ||||| N N -H ||||| O-Asp
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