In the charming little world of Final Fantasy VII, there's a good-sized amusement park area with a battle arena in which you could have fun taking on various monsters while suffering random status effects.
After a few rounds in this arena, the game asks Cloud whether he wants to continue. He heartily replies:
No way! (or) Off course!
And, much to the beguilement of native English-speakers, Cloud remains on course, of course.
The practical uses for this phrase include keeping it in your verbal arsenal to launch out totally at random, in hopes of attracting the attention of another Final Fantasy VII fan, whereupon you shall both smile knowingly at each other and walk away more satisfied; or appearing a little psycho to all passerby who shall respectfully keep their distance and wonder to themselves why you choose to joyfully announce your bad sense of direction...