The Mid-Ohio Valley is the name given to the southeastern portion of Ohio and the adjoining area in West Virginia, primarily Washington County, Ohio, and Wood County, West Virginia.

Communities in the heart of the Mid-Ohio Valley inlcude Parkersburg, West Virginia, Marietta, Ohio, Athens, Ohio, Vienna, West Virginia, and Devola, Ohio.

NBC affiliate WTAP-TV15 claims to be the source of news for the Mid-Ohio Valley.

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