The Grunstein and Hogness method is a
hybridization lab technique in which whole,
lysed (ruptured)
bacterial colonies which have previously been blotted onto a
nitrocellulose (or other)
membrane are
hybridized to a
DNA probe.
The information in this writeup was taken from the science dictionary at http://biotech.icmb.utexas.edu/; I oversaw the development of the dictionary. For copyright details, see the BioTech homenode.