Greig cephalopolysyndactyly is a rare syndrome affecting human growth and development. This syndrome causes abnormalities in various body features.

Etymological Primer

  • Poly: Having more than one.
  • Dactyl: Latin (dactylus) for finger or toe; digit.
  • Syn: With, together.
  • Macro: Greek (makros) for large.
  • Cephalic: Latin (cephalicus) for head.

Charateristic Anomalies

  • Polydactyly: Having superfluous fingers or toes.
  • Cutaneous Syndactyly: Having webbed fingers or toes.
  • Macrocephaly: Having an extremely large head.
  • Ocular Hypertelorism: Eyes spaced too far apart.
  • Frontal Bossing: A high, prominent forehead.
  • Seizures and Mental retardation are rare.

Genetic Basis

GCPS is related to the encoding of chromosome 7, specifically a gene known as GLI3. This gene is involved in the shaping and patterning of organs. GCPS can be caused by either a mutation in the section of Chromosome 7 that contains GLI3, or by a mutation in the gene itself, which retards viable protein synthesis. The condition is autosomal dominant; a person with CCPS is 50% likely to pass the condition to their children.


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