The ancient work will be accomplished,
And from the roof evil ruin will fall on the great man:
They will accuse an innocent, being dead, of the deed:
The guilty one is hidden in the misty copse.
JFK was shot from the top floor of a book depository building. Oswald was shot while being transferred by the police and was assigned blame, although there has been much controversy over whether or not Oswald really did it. According to this prediction by Nostradamus, he didn't.
Granted, it's a pretty general description that could apply to a lot of circumstances...