Charcot-Marie-
Tooth Syndrome (CMT) is a
genetic condition of the peripheral
nervous system that affects the sensory and
muscle control of
nerves in the lower legs and arms. It was named for the three scientists who first noted it around the start of the 20th century.
CMT is characterized by a slowly progressive degeneration of the muscles in the foot, lower leg, hand and forearm, and a mild loss of sensation in the limbs, fingers and toes. Degeneration reaches its peak usually by about age 30, but CMT is not a fatal disease and does not affect normal life expectancy.
CMT is a genetically heterogeneous disorder, in which mutations in different genes can produce the same clinical symptoms.
Those suffering from CMT have been found to benefit greatly from a regular exercise program, which can help to maintain good movement control and to prevent stiffness and contractures.