The cell-mediated response is part of the immune response
T cells are responsible fo this response
. They differentiate under the influence of the thymus
and respond to bacteria
and viruses within infected body cells
, also cancer cells
and transplanted tissues
engulfs a bacteria and antigens
are stripped and put on receptors
which are presented on the surface of the macrophage. This antigen is presented to a virgin T cell. The T cell
receptor must recognize botht the MHC
-II protein and the specific antigen fragment to bind.
protein also helps secure the relationship between the macrophage and the T cell.
The T cell becomes activated
and divides into helper T cell
s, cytotoxic T cell
The helper T cells help activate B
cells in the humoral response.
The T cells also secrete
interleukins, some of which cause a fever or help differentiation
of other T cells.
The cytotoxic T cells are the effectors
of the cell-mediated response. They search and destroy
infected cells by secreteing chemicals that punches holes
in the infected cell's membrane
, causing lysis